GEVI Sensor Comparison

Neuroscience
Methods
Voltage Imaging
Comparison table of genetically encoded voltage indicators across kinetics, sensitivity, excitation wavelength, and model-organism usage.
Author

Mursel Karadas

Published

May 31, 2026

Keywords

GEVI, voltage sensors, imaging, microscopy, comparison

Measurement in non-neuronal cell culture unless otherwise stated.

Name \(\tau_{fast}\) (ms) % \(\tau_{fast}\) \(\tau_{slow}\) (ms) %\(\Delta F/F\) / 10mV \(\lambda_{ex}\) (nm) Mouse Drosophila Zebrafish Source Notes
Jarvis N/A 2.9 470/940 3 X (Grimm et al., 2024)
pAce 0.5 82 1.5 3.1 505/940 X X (Grimm et al., 2024; Kannan et al., 2022)
pAceR 2.4 54 5.4 2.8 565 X X (Kannan et al., 2022)
Jedi-2P 0.5 88c 7.8c -4.8 501/940 X (Liu et al., 2022)
Jedi-1P 0.53 89c 10.3c -5.4 470 5 (Lu et al., 2023) d, e
ASAP6b 3.7 100 16 470/960 X (Lee et al., 2024)
ASAP6.1 4.0 100 20 470/960 X (Lee et al., 2024)
Voltron2 0.7 3.3 -3.5 525f/1135 X X X (Abdelfattah et al., 2023; Brooks et al., 2024) f
Positron 1.8 525f X (Abdelfattah et al., 2020) f, g, h
Positron2 3.7 X (Schreiter et al., 2023; Wang et al., 2023) f, h
QuasAr6a 1.8 90 6.3 7.3g 635 X (Tian et al., 2023)
QuasAr6b 0.8 87 6.6 2.4c 635 X (Tian et al., 2023)
Archon1 0.61 88 8.1 4.3h 637 X X (Piatkevich et al., 2019, 2018) b

Footnotes

  • b: Half rise time: 1.9 ms
  • c: Organotypic slices
  • d: At 32 C - 35 C
  • e: Only widefield w/o single cell resolution reported
  • f: With dye JF525, other dyes possible
  • g: In cultured neurons: 4.7% / 10 mV
  • h: In cultured neurons

Bibliography

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